Analisis Potensi Farmakokinetik dan Toksisitas Pada Curcumin (Curcuma xanthorrhiza) Sebagai Brightening Terhadap Reseptor Protein Tirosinase Secara in Silico

Tyrosinase enzyme is an that plays important role in melanin synthesis. This will oxidize the amino acid L-tyrosine into L- 3,4 dihydroxyphenylalanine (L-DOPA) and convert L-DOPA DOPAquinone. protein from Bacillus megaterium complex with inhibitor kojic target interact ligand (Drug Candidate), Temulawak (Curcuma xanthorrhiza) one of medicinal plants Zingiberaceae family which widely grown used as a raw material for traditional medicine Indonesia, main content curcumin has antioxidant properties. Antioxidants can be ingredients whitening preparations. In silico tests are to predict pharmacokinetic activity toxicity by docking using Molegro Virtual Docker computer program. The receptor was Protein PDB code 3NQ1 KOJ_B_1351. Prediction properties (ADME) Curcumin Kojic Acid performed pkCSM online tool Data analysis comparing binding energy results between Curcumin, Acid, on receptor. test showed Kurkumin =-142.766 kcal/mol, = -60.6899 KOJ_B_1351 =-62.266 kcal/mol. program show compounds have good properties, cause relatively low toxicity, candidates materials.